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pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can cut down panobinostat ranges by ~70% and result in remedy failure.pentobarbital will lower the extent or effect of eltrombopag by impacting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Check.bupren